In patients with the stent-mounted procine xenograft in the aortic position, we have found the A2 Multipurpose catheter to be the fastest and most predictable means of entering the left ventricle from the groin. Potential complications of retrograde left ventricular catheterization in patients with aortic valve prostheses are discussed.
The authors report on 9 cases of mediterranean visceral leishmaniasis (Kala-Azar) collected in the south-eastern part of France in 1978. They emphasize the more frequent occurrence of this disease in adults than children. Out of the 40 cases detected in this region between January 1975 and December 1978, 22 affected adults (55 percent) moreover, Kala-Azar appears to occur particularly in adults with decreased general resistance and diagnosis may be difficult because classical clinical features are no complete.
A spontaneous stercoral fistula containing pinworms was observed in a patient, 35 years after an appendicectomy. The various surgical complications of oxyuriasis are reviewed, in particular, the possibilities for the parasite to traverse the intestinal wall.
In the case reported here, it appears that infiltration occurred in the external wall of the caecum. Vegetable extracts prepared with 530 species belonging to 120 botanical families are biologically screened with fourth stage larvae of Aedes aegypti.
Crystalline 4-(SR)-sulfidocyclophosphamides, sulfido derivatives of activated cyclophosphamide (4-hydroxycyclophosphamide), were synthesized by ozonation of cyclophosphamide and reaction of the intermediate 4-hydroxycyclophosphamide with various thiols (HSR).
The products were characterized by elemental analysis, 1H NMR and IR spectroscopy, and mass spectrometry. 1H NMR and polarimetric analysis demonstrated that they consist of racemic cis-isomers that are stable in the crystalline state at room temperature.
In aqueous solution these derivatives are hydrolyzed to 4-hydroxycyclophosphamide and the corresponding thiol, with half-lives ranging between 4 and 17 min at 37 degrees C and pH 7. The cytotoxicity of 4-(S-ethyl)- and 4-(S-ethanol)-sulfidocyclophosphamide against Yoshida sarcoma ascites cells and the toxicity in rats were found to be practically identical with those of activated cyclophosphamide.
A preliminary evaluation of the curative effect after a single IV injection of 4-(S-ethane)- and 4-(S-ethanol)-sulfidocyclophosphamide in rats bearing Yoshida ascites sarcoma or of 4-(S-ethanol)-sulfidocyclophosphamide in nu/nu mice bearing human breast carcinoma xenografts suggested that these sulfido derivatives possess the same oncostatic efficacy as activated cyclophosphamide itself.
Pattern differentiation was tested as soon as infants could be taken out of the incubator. Preference could be observed from 31 weeks post-conceptional age. Both functions showed comparable maturation to full-term controls by 34 weeks gestation. The development of the binocular reflexes during the first 6 months of life was studied in 38 normal infants.
Preliminary results indicate that the following reflex is well established by 2 months, convergence by 3 months and the corrective fusion reflex by the age of 5 months.
The authors assessed visual functions in 10 children after operations for congenital glaucoma. All the children had had one or more operations previously and it was found that the visual development of the child was affected. A sample of 583 Yugoslav urban children aged between 3 and 7 years, was tested for refraction. It was found that hypermetropia decreased between the ages of 3 and 6, but increased in the seventh year confirming other studies in this area.
A method is described for the determination of 3-mercaptolactate, mercaptoacetate (thioglycolate) and N-acetylcysteine in urine. As these compounds are mainly excreted as their mixed disulfides with cysteine, they are first reduced to the free thiols by an insoluble polymer containing thiol groups.